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Supplementary Figure 4 from Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 60K, CAOV3 (an ovarian cancer cell line) was untreated, cultured with tocilizumab or cisplatin. After 24h, intracellular pSTAT-levels were measured by flow cytometry. A) Example of staining pSTAT3 for CAOV3, CAOV3 treated with tocilizumab and CAOV3 treated with cisplatin. B) Geometric mean (background subtracted is depicted. Representative experiment of three experiments. CAOV3 treated with cisplatin shows an increased pSTAT3 and decreased pSTAT1 and 6. Treatment with Tocilizumab reduced STAT3 activation.

DOI: 10.1158/0008-5472.22399634

Authors: Eveline M. Dijkgraaf, Moniek Heusinkveld, Bart Tummers, Lisa T.C. Vogelpoel, Renske Goedemans, Veena Jha, Johan W.R. Nortier, Marij J.P. Welters, Judith R. Kroep, Sjoerd H. van der Burg

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362420008

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