Work

Supplementary Figures 1 through 6 from Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling

Year: 2023

Type: supplementary-materials

Abstract: PDF - 3180K, Figure S1. Chloroquine does not affect differentiated cancer cells. Figure S2. Chloroquine eliminates pancreatic cancer stem cells. Figure S3. Autophagy is not mediating the effect of chloroquine on primary PDAC cells. Figure S4. Chloroquine has no effect on cell migration of non-CSCs Figure S5 - Chloroquine displays negative in vitro effect on the Shh signaling. Figure S6. Inhibitory in vivo effect of chloroquine on stromal hedgehog signaling and expansion of the stroma.

DOI: 10.1158/1535-7163.22500096

Authors: Anamaria Balic, Morten Dræby Sørensen, Sara Maria Trabulo, Bruno Sainz, Michele Cioffi, Catarina R. Vieira, Irene Miranda-Lorenzo, Manuel Hidalgo, Joerg Kleeff, Mert Erkan, Christopher Heeschen

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4362493971

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