Supplementary Figure 1 from The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity
Year: 2023
Type: supplementary-materials
Abstract: (A) Mice were inoculated with 0.5 million Raji-ffluc cells via tail vein injection and tumor engraftment was confirmed by bioluminescence imaging on day six. On day seven, mice received a single i.v. injection of various doses of CD8+ TCM-derived T-cells transduced with the short spacer CD19/4-1BB/CD3ζ-CAR or of control T-cells (EGFRt). (B) Tumor growth was measured by bioluminescence imaging and is plotted for individual mice (4 mice per group). Arrows mark the day of T-cell transfer. Bioluminescence images from day six (one day before T-cell transfer) and day 19 (12 days after transfer) are shown.
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4362552735