A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status
Year: 2023
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: There is an urgent need for novel blood biomarkers for the detection of Alzheimer's disease (AD). We previously showed that levels of the bisecting N-acetylglucosamine glycan epitope was elevated in cerebrospinal fluid in AD. However, its diagnostic value in blood is unknown. METHODS: We analyzed blood levels of bisecting N-acetylglucosamine and total tau in a retrospective cohort of 233 individuals. Progression to AD was compared between the groups using Cox regression. The predictive value of the biomarkers was determined by logistic regression. RESULTS: Bisecting N-acetylglucosamine correlated with tau levels (p < 0.0001). Individuals with an intermediate tau/bisecting N-acetylglucosamine ratio had elevated AD risk (hazard ratio = 2.06, 95% confidence interval [CI]: 1.18-3.6). Moreover, a combined model including tau/bisecting N-acetylglucosamine ratio, apolipoprotein E (APOE) ε4 status, and Mini-Mental State Examination score predicted future AD (area under the curve = 0.81, 95% CI: 0.68-0.93). DISCUSSION: Bisecting N-acetylglucosamine in combination with tau is a valuable blood biomarker for predicting AD.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.13024
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
Awards: Development of novel modulators of molecular chaperone network with focus on Alzheimer disease therapy, PREDEM: precision diagnostics and treatment och cognitive disorders and prevention of dementia, G345393138, Genetic code expansion in neurons to elucidate pathogenic mechanisms in Alzheimer disease, G4404751248, G5162906339, G552184065, G6388562612, Disentangling complexity of health in aging: A new research environment to pave the road for individualized medicine, Biomarker signatures of progressing multimorbidity: in pursuit of personalized approaches to clinically complex older individuals, G712881263, G7143958211, Not all older adults develop dementia: exploring underlying compensatory mechanisms related to healthy brain aging, G79462076, G8163365334, G874515679
OpenAlex ID: W4365136142