Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis (Adv. Sci. 11/2023)
Year: 2023
Type: article
Abstract: T Cell homeostasis The article number 2206344 by Yuxin Yin, Xuehui Zhang, Xuliang Deng, Dan Lu, and co-workers uncovers that peripheral T cells can undergo necroptosis instead of apoptosis when endogenous RPA1 is deleted, which leads to severe lymphopenia and increases the susceptibility of autoinflammatory diseases. Accordingly, chemical or genetic inhibition of necroptosis signaling can ameliorate the inflammatory damage by Rpa1 deficiency and restore host immune homeostasis.
Source: Advanced Science
Authors: Jia Song, Xin Zhang, Yue Yin, Mengfan Guo, Xuyang Zhao, Likun Wang, Caixia Ren, Yuxin Yin, Xuehui Zhang, Xuliang Deng, Dan Lu
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,720
OpenAlex ID: W4365505145