Work

Full Regio- and Stereoselective Protocol for the Synthesis of New Nicotinoids via Cycloaddition Processes with the Participation of Trans-Substituted Nitroethenes: Comprehensive Experimental and MEDT Study

Year: 2023

Type: article

Abstract: [3 + 2] Cycloaddition reactions with the participation of Z-C-(3-pyridyl)-N-methylnitrone and series of E-2-R-nitroethenes were both experimentally and theoretically explored in the framework of Molecular Electron Density Theory. It was found that all considered processes are realized under mild conditions and in full regio- and stereocontrol. The ELF analysis additionally showed that the studied reaction proceeds by a two-stage, one-step mechanism.

Source: Molecules

DOI: 10.3390/molecules28083535

Authors: Jowita Kras, Przemysław Woliński, Roman Nagatsky, Oleg M. Demchuk, Radomir Jasiński

Institutions: Cracow University of Technology, John Paul II Catholic University of Lublin

Language: English

Topic: Organic Chemistry Cycloaddition Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,558

OpenAlex ID: W4366293760

FWCI: 0.876

Cites: 41

Cited by: 9

Related to: 10