WHSC1 is involved in DNA damage, cellular senescence and immune response in hepatocellular carcinoma progression
Year: 2023
Type: article
Abstract: Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is a transcriptional regulatory protein that encodes a histone methyltransferase to control H3K36me2 modification. WHSC1 was upregulated and associated with poor prognosis in HCC. The elevated WHSC1 likely due to the alterations of DNA methylation or RNA modification. WHSC1 perhaps form a chromatin cross talk with H3K27me3 and DNA methylation to regulate transcription factors expression in HCC. Functional analysis indicated that WHSC1 was involved in DNA damage repair, cell cycle, cellular senescence and immune regulations. Furthermore, WHSC1 was associated with the infiltrating levels of B cell, CD4+, Tregs and macrophage cells. Therefore, our findings suggested that WHSC1 might function as a promotor regulator to affect the development and progression of HCC. Thus, WHSC1 could be a potential biomarker in predicting the prognosis and therapeutic target for patients with HCC.
DOI: 10.1111/jcmm.17743
Authors: Jia Yan, Ming Yang Zhang, Jing Lin, Ke Xin Li, Zhi Min Zhao, Yu Min Gao, Xiu Ling Deng, Chang Shan Wang, Hai Sheng Wang
Institutions: Inner Mongolia Medical University, Inner Mongolia University
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,510
OpenAlex ID: W4366352820