Does the Body Mass Index (bmi) Impact the Overall Survival (os) of Brazilian Women With Breast Cancer (bc) Who Have Achieved Pathological Complete Response (pcr) After Neoadjuvant Chemotherapy (nct)?
Year: 2022
Type: conference-abstract
Abstract: Objective: This study aimed to evaluate the impact of obesity on the survival of patients with breast cancer (BC) treated with neoadjuvant chemotherapy (NCT) in two public hospitals in Brazil. Methods: This is a retrospective, multicenter study that evaluates women with BC at Pérola Byington (HPB) and State Public Servant (HSPE) hospitals between January 2011 and May 2020. Stages I–III, age ≥18 years, and who underwent NCT were included. Patients were categorized by the World Health Organization definition as follows: body mass index (BMI) < 18.5 kg/m2 : malnutrition; 18.5 to < 25 kg/m2 : normal; 25 to < 30 kg/m2 : overweight; ≥30 kg/m2 : obesity. Pathological complete response (pCR) was defined as the absence of invasive breast and axillary tumors. T-test or chi-square test was used to individually analyze the association of each variable between groups with and without pCR. Univariate and multivariate analyses were performed to calculate odds ratios, 95% confidence intervals of the independent variables BMI, age, and clinical stage, correlated with pCR with p-value <0.05 as statistically significant. Results: We enrolled 1779 patients, mean age of 50 years, and mean BMI of 28.08 kg/m2 . Most of them were in stage III (68%) with ductal histological type (95.11%). After NCT, 1435 patients had residual disease and 344 patients had pCR. The BMI ratio was 1.57% malnutrition, 30.58% normal, 35.13% overweight, and 32.72% obese. When the pCR was associated with BMI, there was no significance on overall survival (OS) when evaluating separate centers (HPB: p=0.46, HSPE: p=0.49) or together (p=0.83). Disease-free survival was only possible in HPB without significance (p=0.83) for BMI. Conclusion: This Brazilian study showed no interference of BMI on OS in patients submitted to NCT with pCR. There were few patients achieving pCR (19.34%) probably because of the initial stage. Despite not having an impact on survival, most of our women were overweight or obese (72.85%), showing how obesity is common in Brazilian women and should be understood as a public health problem.
Source: Mastology
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4366705260