Work

Chemical constituents from the heterotrophic marine microalgae Aurantiochytrium sp. SC145 and their antimicrobial activities

Year: 2023

Type: article

Abstract: One new indol, N-methoxymethyltryptophol (1), one new phenolic, (2 R)-2-(4-hydroxyphenyl)ethyl 2-hydroxy-3-phenylpropanoate (2) and fifteen known compounds (3–17) were isolated from the methanol extract of the fermentation of marine microalgae Aurantiochytrium sp. SC145. Their structures were elucidated by 1D-, 2D-NMR spectroscopic analysis, HR-ESI-MS, quantum chemical calculation methods and by comparing their NMR data with those reported in the literature. All compounds were evaluated for their antimicrobial activities against microorganisms. Compounds 2, 3 and 11 significantly exhibited antimicrobial activities on all tested Gram-(+), Gram-(-) bacteria and the yeast C. albicans with MIC values ranging from 32 to 256 µg/mL.

Source: Natural Product Research

DOI: 10.1080/14786419.2023.2201882

Authors: Nguyen Thi Thu Thuy, Hoang Thi Minh Hien, Nguyen Cam Ha, Le Thi Thom, Dang Diem Hong, Nguyen Van Thinh, Nguyen Trong Dan, Nguyen Dang Hoi, Vu Thi Loan, Hoang Duc Quang, Dan Thi Thuy Hang, Phan Van Kiem, Bui Huu Tai, Nguyen Thi Minh Hang, Nguyen Tien Dat, Nguyen Xuan Nhiem

Institutions: Joint Vietnam-Russia Tropical Science and Technology Research Center, Graduate University of Science and Technology, Vietnam Academy of Science and Technology

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W4366757252

FWCI: 0.763

Cites: 22

Cited by: 7

Related to: 10