Year: 2023
Type: review
Abstract: As the thymus involutes during aging, the T-cell pool has to be maintained by the periodic expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of activation and proliferation drive the differentiation of T cells toward replicative senescence, due to telomere erosion. This review discusses mechanisms that regulate the end-stage differentiation (senescence) of T cells. Although these cells, within both CD4 and CD8 compartments, lose proliferative activity after antigen-specific challenge, they acquire innate-like immune function. While this may confer broad immune protection during aging, these senescent T cells may also cause immunopathology, especially in the context of excessive inflammation in tissue microenvironments.
Source: Immunological Reviews
DOI: 10.1111/imr.13206
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,530
Awards: Senescent CD8+ T and NK cells contribute to immunopathogy duting cutaneous leishmaniasis, G5267350807, G5385638322, G6879108501, How does blocking inflammation enhance human cutaneous immunity during ageing in vivo?, G809499716, The integration of human T cell senescence and function at the molecular level
OpenAlex ID: W4366997475