Work

New approaches in the detection of neutralizing antibodies using SARS-CoV-2 as a model

Year: 2023

Type: conference-abstract

Abstract: The Plaque Reduction Neutralization Test (PRNT) is considered the gold standard to study Neutralizing Antibodies (NAbs), but due to its limitations, more scalable approaches are required. Focus Reduction Neutralization Test (FRNT) is suitable for automation which allows large-scale testing and data integrity. SARS-CoV-2 PRNT and FRNT must be held in Biosafety Level 3 (BSL-3) labs. To circumvent this issue, the use of SARS-CoV-2 Pseudovirus (PV) has enabled the manipulation in BSL-2 areas, increasing throughput and reducing costs.

Source: Symposium: Building Pathways to Accelerate the Development of the National Technological Innovation Ecosystem

DOI: 10.35259/isi.2023_57991

Authors: Caio Denani, Bruno Setatino, Ingrid Horbach, Nathalia Alves, Adriana Azevedo, Gabriela Esteves, Elena Caride, Waleska Schwarcz, Ivanildo Júnior, Sheila Lima

Institution: Instituto de Tecnologia em Imunobiológicos

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4367155668

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