The contribution of historical processes to contemporary extinction risk in placental mammals
Year: 2023
Type: article
Abstract: Species persistence can be influenced by the amount, type, and distribution of diversity across the genome, suggesting a potential relationship between historical demography and resilience. In this study, we surveyed genetic variation across single genomes of 240 mammals that compose the Zoonomia alignment to evaluate how historical effective population size ( N e ) affects heterozygosity and deleterious genetic load and how these factors may contribute to extinction risk. We find that species with smaller historical N e carry a proportionally larger burden of deleterious alleles owing to long-term accumulation and fixation of genetic load and have a higher risk of extinction. This suggests that historical demography can inform contemporary resilience. Models that included genomic data were predictive of species’ conservation status, suggesting that, in the absence of adequate census or ecological data, genomic information may provide an initial risk assessment.
Source: Science
Authors: Aryn P. Wilder, Megan A. Supple, Ayshwarya Subramanian, Anish Mudide, Ross Swofford, Aitor Serres-Armero, Cynthia Steiner, Klaus-Peter Koepfli, Diane P. Genereux, Elinor K. Karlsson, Kerstin Lindblad-Toh, Tomas Marques-Bonet, Violeta Munoz Fuentes, Kathleen Foley, Wynn K. Meyer, Oliver A. Ryder, Beth Shapiro, Gregory Andrews, Joel C. Armstrong, Matteo Bianchi, Bruce W. Birren, Kevin R. Bredemeyer, Ana M. Breit, Matthew J. Christmas, Hiram Clawson, Joana Damas, Federica Di Palma, Mark Diekhans, Michael X. Dong, Eduardo Eizirik, Kaili Fan, Cornelia Fanter, Nicole M. Foley, Karin Forsberg-Nilsson, Carlos J. Garcia, John Gatesy, Steven Gazal, Diane P. Genereux, Linda Goodman, Jenna Grimshaw, Michaela K. Halsey, Andrew J. Harris, Glenn Hickey, Michael Hiller, Allyson G. Hindle, Robert M. Hubley, Graham M. Hughes, Jeremy Johnson, David Juan, Irene M. Kaplow, Elinor K. Karlsson, Kathleen C. Keough, Bogdan Kirilenko, Klaus-Peter Koepfli, Jennifer M. Korstian, Amanda Kowalczyk, Sergey V. Kozyrev, Alyssa J. Lawler, Colleen Lawless, Thomas Lehmann, Danielle L. Levesque, Harris A. Lewin, Xue Li, Abigail Lind, Kerstin Lindblad-Toh, Ava Mackay-Smith, Voichita D. Marinescu, Tomas Marques-Bonet, Victor C. Mason, Jennifer R. S. Meadows, Wynn K. Meyer, Jill E. Moore, Lucas R. Moreira, Diana D. Moreno-Santillan, Kathleen M. Morrill, Gerard Muntané, William J. Murphy, Arcadi Navarro, Martin Nweeia, Sylvia Ortmann, Austin Osmanski, Benedict Paten, Nicole S. Paulat, Andreas R. Pfenning, BaDoi N. Phan, Katherine S. Pollard, Henry E. Pratt, David A. Ray, Steven K. Reilly, Jeb R. Rosen, Irina Ruf, Louise Ryan, Oliver A. Ryder, Pardis C. Sabeti, Daniel E. Schäffer, Aitor Serres, Beth Shapiro, Arian F. A. Smit, Mark Springer, Chaitanya Srinivasan, Cynthia Steiner, Jessica M. Storer, Kevin A. M. Sullivan, Patrick F. Sullivan, Elisabeth Sundström, Megan A. Supple, Ross Swofford, Joy-El Talbot, Emma Teeling, Jason Turner-Maier, Alejandro Valenzuela, Franziska Wagner, Ola Wallerman, Chao Wang, Juehan Wang, Zhiping Weng, Aryn P. Wilder, Morgan E. Wirthlin, James R. Xue, Xiaomeng Zhang
Institutions: Howard Hughes Medical Institute, University of California, Santa Cruz, Broad Institute, Phillips Exeter Academy, Universitat Pompeu Fabra, Institut de Biologia Evolutiva, Smithsonian Institution, George Mason University, ITMO University, Smithsonian Conservation Biology Institute, National Zoological Park, University of Massachusetts Chan Medical School, Uppsala University, Science for Life Laboratory, Institució Catalana de Recerca i Estudis Avançats, Universitat Autònoma de Barcelona, Barcelona Institute of Science and Technology, Centre for Genomic Regulation, Institut Català de Paleontologia Miquel Crusafont, European Bioinformatics Institute, University of Iowa, Lehigh University, University of California San Diego, Texas A&M University, University of Maine, University of California, Davis, University of East Anglia, Genome British Columbia, Pontifícia Universidade Católica do Rio Grande do Sul, University of Nevada, Las Vegas, University of Nottingham, Texas Tech University, American Museum of Natural History, University of Southern California, Institute of the Environment, Goethe University Frankfurt, Senckenberg Research Institute and Natural History Museum Frankfurt/M, LOEWE Centre for Translational Biodiversity Genomics, Institute for Systems Biology, University College Dublin, Carnegie Mellon University, Gladstone Institutes, University of California, San Francisco, Yale University, University of Bern, Pasqual Maragall Foundation, Barcelonaβeta Brain Research Center, Harvard University, Canadian Museum of Nature, Case Western Reserve University, Leibniz Institute for Zoo and Wildlife Research, University of Pittsburgh, Chan Zuckerberg Biohub San Francisco
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Awards: G1198869615, G1412445781, GENETICS OF TOBACCO AND ALCOHOL RELATED CANCERS, G3790607131, Enabling Comparative Pangenomics, G434337789, G4848019596, The 200 mammals project: sequencing genomes by a novel cost-effective method, yielding a high resolution annotation of the human genome., G5664680646, G5922694229, G6960046897, G7523051620, G775295145, Genetics and Biology of Malignant Glioma, GENCODE: comprehensive gene annotation for human and mouse, G954154539
OpenAlex ID: W4367173643