Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing
Year: 2023
Type: article
Study design: Systematic Review
Abstract: INTRODUCTION: Previous meta-analyses have linked social connections and mild cognitive impairment, dementia, and mortality. However, these used aggregate data from North America and Europe and examined a limited number of social connection markers. METHODS: = 3.22 years) from 13 longitudinal ageing studies. A two-stage meta-analysis of Cox regression models examined the association between social connection markers with our primary outcomes. RESULTS: We found associations between good social connections structure and quality and lower risk of incident mild cognitive impairment (MCI); between social structure and function and lower risk of incident dementia and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality. DISCUSSION: Different aspects of social connections - structure, function, and quality - are associated with benefits for healthy aging internationally. HIGHLIGHTS: Social connection structure (being married/in a relationship, weekly community group engagement, weekly family/friend interactions) and quality (never lonely) were associated with lower risk of incident MCI. Social connection structure (monthly/weekly friend/family interactions) and function (having a confidante) were associated with lower risk of incident dementia. Social connection structure (living with others, yearly/monthly/weekly community group engagement) and function (having a confidante) were associated with lower risk of mortality. Evidence from 13 longitudinal cohort studies of ageing indicates that social connections are important targets for reducing risk of incident MCI, incident dementia, and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.13072
Authors: Gowsaly Mahalingam, Suraj Samtani, Ben Chun Pan Lam, Darren M Lipnicki, Maria Fernanda Lima‐Costa, Sergio Luis Blay, Erico Castro‐Costa, Xiao Shifu, Maëlenn Guerchet, Pierre‐Marie Preux, Antoine Gbessemehlan, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Themis Dardiotis, Ki‐Woong Kim, Steffi Riedel‐Heller, Susanne Röhr, Alexander Pabst, Suzana Shahar, Katya Numbers, Mary Ganguli, Tiffany F. Hughes, Chung‐Chou H. Chang, Michael Crowe, Tze Pin Ng, Xinyi Gwee, Denise Qian Ling Chua, Joanna Rymaszewska, Karin Wolf‐Ostermann, Anna‐Karin Welmer, Jean Stafford, René Mélis, Myrra Vernooij‐Dassen, Yun‐Hee Jeon, Perminder S Sachdev, Henry Brodaty
Institutions: UNSW Sydney, Centre for Healthy Brain Ageing, La Trobe University, Fundação Oswaldo Cruz, Universidade Federal de São Paulo, Shanghai Jiao Tong University, Shanghai Mental Health Center, Inserm, Centre Hospitalier Universitaire de Limoges, Institut d’Epidémiologie et de Neurologie Tropicale, Institut de Recherche pour le Développement, Université de Limoges, Sahlgrenska University Hospital, Region Västra Götaland, University of Gothenburg, National and Kapodistrian University of Athens, Columbia University Irving Medical Center, Columbia University, Harokopio University of Athens, University of Thessaly, Seoul National University, Seoul National University Bundang Hospital, Leipzig University, Trinity College Dublin, Massey University, National University of Malaysia, University of Pittsburgh, Youngstown State University, University of Alabama at Birmingham, National University of Singapore, University of Wrocław, Wroclaw Medical University, University of Bremen, Karolinska Institutet, MRC Unit for Lifelong Health and Ageing, University College London, Radboud University Nijmegen, Radboud University Medical Center, The University of Sydney
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,000
Funders: Alzheimer's Association, Biogen, University of Pittsburgh, EU Joint Programme – Neurodegenerative Disease Research, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, University of New South Wales, AXA Research Fund, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Eisai, Vetenskapsrådet, Financiadora de Estudos e Projetos, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Forskningsrådet om Hälsa, Arbetsliv och Välfärd, Dementia Australia, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Institute on Aging
Awards: Neurocognitive disorders in the elderly, Social Health And Reserve in the Dementia patient journey (SHARED), G1563533746, G1920100792, Epidémiologie des démences en Afrique Centrale, G2183984161, G2311802219, G2473454548, Physiological resilience: mechanisms and consequences, G2938177328, G3038135699, Cohorts and data collection, Risk factors, early diagnosis, and effective interventions for neurocognitive disorders, Mental Ageing, G4785564444, G6935211943, G712881263, Neurocognitive disorders in the elderly, Social Health And REserve in the Dementia patient journey (SHARED), Mild Cognitive Impairment: A Prospective Community Study
OpenAlex ID: W4367174846