Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915
Year: 2023
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Here, we report a novel, efficient ruthenium-catalyzed direct asymmetric reductive amination of an α-alkoxy ketone, a structural motif for which it is more challenging to implement such a transformation than 1,3-dicarbonyl compounds. The discovery of a novel ruthenium catalyst that was highly stable to air and moisture, as well as being readily prepared from commercially available reagents, enabled rapid access to a key synthetic chiral primary amine en route to TAK-915, an active pharmaceutical ingredient for a PDE2A inhibitor.
Institution: Takeda (Japan)
Language: English
Subfield: Inorganic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $5,000
OpenAlex ID: W4367185707