Year: 2023
Type: preprint
Study design: Observational Study
Abstract: Prostate cancer is one of the most common cancers among workers of various industries that depend on nickel extensively, through different mechanisms. Our present study is designed to estimate nickel concentrations in serum samples from patients with prostate cancer compared to the control group of healthy subjects. The study was carried out on 43 patients with prostate cancer at Al-Biruni University Hospital for Cancerous Diseases in Syria compared with 35 healthy controls. All measurements of serum were done with a graphite atomic absorption spectrophotometer equipped with a deuterium lamp. Our results showed that patients with prostate cancer had significantly higher serum levels of Ni than healthy controls (p < 0.0001). These findings suggest that increased nickel serum levels are associated with an increased risk of prostate cancer in industrial workers through one of the carcinogenic mechanisms.
Source: Research Square
Authors: Feras Brrow, Sophie Barguil
Institution: Damascus University
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4367308306