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Design, Synthesis and Characterization of Novel 1H-1,2,3-Triazole Quinoline-Isatin Tethered Conjugates

Year: 2023

Type: article

Abstract: Quinoline is an important heterocyclic scaffold which is found in a variety of natural compounds (cinchona alkaloids) and therapeutically active drugs with various biological functions. Because of its varied chemical and pharmacological characteristics, quinoline and its derivatives have long drawn the attention of both synthetic and biological chemists. A newer class of quinoline-isatin tethered 1,2,3-triazole conjugates was synthesized in this context, using copper-promoted click chemistry with various organic systems. Ten derivatives of 1,2,3-triazole-tethered 8-hydroxyquinoline and 5-chloro-8-hydroxyquinoline derivatives of isatin were synthesized and well characterized by using analytical techniques such as mass spectrometry, IR, 1H NMR and 13C NMR spectroscopy.

Source: Asian Journal of Chemistry

DOI: 10.14233/ajchem.2023.27873

Authors: Ravi Kant, Keshav Kumar Saini, Ravindra Kumar Upadhyay, Nasser Amri, Rakesh Kumar, Lalita S. Kumar

Institutions: Indira Gandhi National Open University, University of Delhi, Jazan University

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

OpenAlex ID: W4367334175

FWCI:

Cites: 32

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Related to: 10