Work

Super Recurrence of Takotsubo Syndrome: Clinical Characteristics and Late Cardiac Outcomes

Year: 2023

Type: article

Abstract: ecurrent takotsubo syndrome (TS) events are uncommon, with reported frequency of 1% to 6%. [1][2][3] There is evidence for late subclinical cardiac dysfunction after a single TS event.4 Patients with multiple TS events might be vulnerable to late cardiac dysfunction, although this scenario has not been examined.To further inform this uncertainty, we evaluated the clinical characteristics and late cardiac outcomes of patients with ≥2 TS recurrences (super recurrence), compared with patients without recurrence.The data that support the findings of this study are available from the corresponding author on reasonable request.From 2001 to 2022, we prospectively followed up 506 consecutive patients with TS from a single US center (average age, 68±13 years; 460 [91%] women; and 9 [1.8%] patients with ≥2 TS recurrences).Because TS recurrence is time dependent, we limited the comparator group (those without recurrence) to 49 (9.7%) patients with ≥10 years of follow-up after index TS event.Median follow-up for patients with super recurrence was 8.0 (interquartile range, 6.2-13.7)years; and for those without recurrence, it was 12.5 (interquartile range, 11.0-14.2) years.TS diagnosis used internationally accepted criteria.2 This study was approved by the Allina Health Institutional Review Board, and subjects gave informed consent.

Source: Journal of the American Heart Association

DOI: 10.1161/jaha.122.029144