French guidelines for the etiological workup of eosinophilia and the management of hypereosinophilic syndromes
Year: 2023
Type: article
Abstract: Eosinophilic-related clinical manifestations are protean and the underlying conditions underpinning eosinophilia are highly diverse. The etiological workup of unexplained eosinophilia/hypereosinophilia can be challenging, and can lead sometimes to extensive, inappropriate, costly and/or invasive investigations. To date, guidelines for the etiological workup and management of eosinophilia are mainly issued by hematologists, and thus mostly cover the scope of clonal hypereosinophilic syndromes (HES). Here, thanks to an extensive literature review, and thanks to the joint work of a large panel of experts involving physicians from both adult and pediatric medicine and from various subspecialties (as well as a representative of a patients' association representative), we provide recommendations for both the step-by step diagnostic workup of eosinophilia (whether unexplained or within specific contexts) as well as the management and follow-up of the full spectrum of eosinophilic disorders (including clonal, reactive, lymphocytic and idiopathic HES, as well as single-organ diseases). Didactic prescription summaries intended to facilitate the prescription of eosinophil-targeted drugs are also provided, as are practical diagnostic and therapeutic algorithms. Lastly, this set of recommendations also includes a summary intended for general practitioners, as well as an overview of the therapeutic patient education program set up by the French reference center for HES. Further updates will be mandatory as new validated information emerges.
Authors: Matthieu Groh, Julien Rohmer, Nicolas Etienne, Wadih Abou Chahla, Antoine Baudet, Aurélie Chan Hew Wai, Cécile Chenivesse, Irena Clisson Rusek, Vincent Cottin, Matthieu Decamp, Pascal De Groote, Fanny Delahousse, Nicolas Duployez, Stanislas Faguer, Frédéric Gottrand, Florent Huang, Thierry Leblanc, Antoine Magnan, Thierry Martin, Geoffrey Mortuaire, Antoine Néel, Luc Paris, Arnaud Petit, Julien Rossignol, Nicolas Schleinitz, Juliette Soret-Dulphy, Delphine Staumont-Salle, Benjamin Terrier, Louis Terriou, Jean-François Viallard, Guillaume Lefèvre, Jean-Emmanuel Kahn
Institutions: Inserm, Université de Lille, Université Paris-Saclay, Centre Hospitalier Universitaire de Lille, Assistance Publique – Hôpitaux de Paris, Hôpital Ambroise-Paré, Hôpital Foch, Institute for Translational Research in Inflammation, Hôpital Bichat-Claude-Bernard, Hôpital Necker-Enfants Malades, Centre Hospitalier Annecy Genevois, Centre National de la Recherche Scientifique, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, French Clinical Research Infrastructure Network, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Hospices Civils de Lyon, Hôpital Louis Pradel, Centre Hospitalier Universitaire de Caen Normandie, Lille’s Cardiology Hospital, Institut pour la Recherche sur le Cancer de Lille, Centre de Recherches en Cancérologie de Lille, Université Toulouse III - Paul Sabatier, Centre Hospitalier Universitaire de Toulouse, Hôpital Jeanne de Flandre, Hôpital Robert-Debré, Hôpitaux Universitaires de Strasbourg, Centre Hospitalier Universitaire de Nantes, Sorbonne Université, Pitié-Salpêtrière Hospital, Hôpital Armand-Trousseau, Hôpital de la Timone, Hôpital Saint-Louis, Centre d'Investigation Clinique Saint-Louis, Centre Hospitalier Universitaire de Bordeaux
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,790
OpenAlex ID: W4367393408