The effect of different doses of levofloxacin on leukocyte dynamics in chicken blood
Year: 2023
Type: article
Abstract: The article deals with research into the effect of different doses of levofloxacin (fluoroquinolone class drug) on chicken blood parameters. Male Hisex Brown chickens were divided into 3 groups, one of them was control, the other two were experimental, the latter received the drug at concentrations 600 mg/L and 200 mg/L. The fluoroquinolone was administered via drinking water 5 consecutive days. We evaluated the following hematological parameters of chickens: leukocyte count (direct count in Goryaev's chamber) and leukogram (count in stained blood smears). The results of our research state that the administration of levofloxacin at concentration 600 mg/L causes transitory leukocytosis, lymphopenia and pseudoeosinophilia, but that does not imply a heavy toxic effect on chicken organism as by the end of the research the parameters were already within the normal range. The administration of levofloxacin at concentration 200 mg/L similarly caused a brief increase in pseudoeosinophil number and a decrease in lymphocyte number in chicken blood but they were not generally marked which would prove the negative effect of levofloxacin.
Source: Veterinaria i kormlenie
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4372271508