Work

Palladium‐catalyzed Asymmetric Oxycarbonylation of Internal Z‐Alkenes

Year: 2023

Type: article

Abstract: Herein we reported the first enantioselective acetoxycarbonylation of internal (Z)‐alkenes, featuring with a sterically hindered Quinox ligand. The desired acetoxyester products, which could be easily transformed into various biologically important molecules, were obtained in moderate to good yields and excellent enantioselectivities, along with good functional groups compatibility. Further transformations of these acetoxyesters into natural product analogous demonstrated the synthetic utility and application of this method.

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.202300165

Authors: Changyu Shao, Chuanqi Hou, Pinhong Chen, Haihui Peng, Guosheng Liu

Institutions: East China Normal University, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, State Key Laboratory of Organometallic Chemistry

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, Science and Technology Commission of Shanghai Municipality