Work

Model-Informed Precision Dosing of Vancomycin in Adult Patients Undergoing Hemodialysis

Year: 2023

Type: article

Abstract: dosing for vancomycin-a loading dose of 30 mg/kg, which achieves the target AUC for 24 h after first dose with a probability of 93.0%, ensured by a predialysis concentration of >15 μg/mL. Maintenance doses of 12 mg/kg after every hemodialysis session could achieve the required exposure, with a probability of 80.6%. In conclusion, this study demonstrated that KoA-predicted hemodialysis clearance may lead to an upgrade from conventional dosing to MIPD for vancomycin in patients undergoing hemodialysis.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00089-23

Authors: Kazutaka Oda, Hirofumi Jono, Hideyuki Saito

Institutions: Kumamoto University Hospital, Kumamoto University

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Nipro, Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science