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Efficient Delivery of GSDMD‐N mRNA by Engineered Extracellular Vesicles Induces Pyroptosis for Enhanced Immunotherapy (Small 20/2023)

Year: 2023

Type: article

Abstract: Engineered Extracellular Vesicles In article number 2204031, Jing Zhao, Guodong Yang, Angang Yang, and co-workers develop an extracellular vesicle-based GSDMD-N mRNA delivery system (EVTx), in which GSDMD-N mRNA is encapsulated inside the vesicle, HER2 antibody is displayed on the surface, and sonosensitizer Ce6 is incorporated into the membrane. When endocytosed by HER2+ cancer cells, EVTx efficiently induces pyroptosis and thus enhances cancer immunotherapy.

Source: Small

DOI: 10.1002/smll.202370141

Authors: Yuqi Xing, Feiyu Zhang, Panpan Ji, Mengying Wei, Chunhui Yin, Angang Yang, Guodong Yang, Jing Zhao

Institutions: Air Force Medical University, Xijing Hospital

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4376879151

FWCI: 0.232

Cites:

Cited by: 3

Related to: 10