Work

A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry

Year: 2023

Type: article

Abstract: Hairy Cell Leukemia is an infrequent leukemia that can be recognized both microscopically and flow cytometrically once the patient develops symptoms. We present a case where early diagnosis was achieved using flow cytometry long before the patient became symptomatic. This was achieved by focusing on a small percentage (0.9%) of total leukocytes that exhibited a higher side scatter and brighter CD19/CD20 than the remaining lymphocytes. A bone marrow aspirate three weeks later confirmed the presence of malignant B-cells. Shortly after, the patient presented splenomegaly and complained of fatigue.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2023.1207443

Authors: James Tadros, Amanda Davis, Oreoluwa Awoleye, Evros Vassiliou

Institutions: Paterson Public Schools, Cancer Care Nova Scotia, Kean University

Language: English

Topic: Chronic Lymphocytic Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295