Multimodal Anti-Inflammatory Approach to Osteoarthritis Management - Review of T Cell Immunomodulation with Undenatured (Native) Collagen Type II, and LOX Inhibition with Boswellia
Year: 2019
Type: article
Abstract: Osteoarthritis, known to be a degenerative disease, is now seeing increasing evidence of also having an inflammatory pathophysiology involving multiple pathways.T cell mediated immune response to joint cartilage collagen is now one of the recognized pathways causing cartilage destruction.T helper cell activation, involvement of pro-inflammatory cytokines and increased destruction of cartilage by Matrix Metalloproteinase enzymes, along with a relative suppression of anti-inflammatory cytokines and T regulatory cells appear to be important inflammatory mechanisms perpetuating continuous cartilage loss.Conversion of Phospholipids released from tissue injury to arachidonate and thereafter to prostaglandins and leukotrienes by the Cyclo-oxygenase 2 (COX2) and Lipo-oxygenase 5 (5LOX) enzymes respectively, is also well known.While COX2 inhibition via Non-steroidal anti-inflammatory drugs is well established in Osteoarthritis, the role of Leukotrienes in increasing inflammatory activity and cartilage destruction requiring appropriate inhibition needs further emphasis.Therefore, controlling cartilage destruction in Osteoarthritis through addressing these multiple inflammatory pathways can be a rational therapeutic approach.This article aims to elaborate on the pharmacotherapeutic approaches involving modulating T cell immune response to cartilage and inhibiting the LOX pathways by Undenatured (Native) Collagen Type II and Boswellia extract respectively.
Institution: BLK Super Speciality Hospital
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4377206486