Work

The relationship between vitamin D and sarkopenia in patients with metabolic syndrome

Year: 2023

Type: article

Abstract: Funding Acknowledgements Type of funding sources: None. Backround: Vitamin D is essential for the optimal function of many bodily systems and it is associated with various types of metabolic illnesses such as obesity, diabetes mellitus, insulin resistance, and cardiovascular diseases including hypertension. Decreased absorption of vitamin D may pose a risk for sarcopenia by affecting the lipid profile responses in metabolic syndrome (MetS). Purpose Our aim is to examine the relationship between vitamin D level and selected sarkopenia parameters such as muscle and fat mass, muscle strength, body composition, and walking speed in patients with MetS. Method 67 patients (mean age=50.3±7.69/years, F:51, M:16) aged 35-65 years and diagnosed with MetS (according to NCEP-ATP III criteria) were included in the study. Body mass index (BMI), muscle and fat mass of the participants were assessed using bioelectrical impedance analysis (TANITA). Waist and hip circumferences were measured. Right and left quadriceps muscle strength (J-Tech CommanderTM Muscle Tester) and grip strength (Jamar dynamometer) of the dominant hand (all patients were right dominant) were measured with dynamometer. Walking speed was calculated by dividing the distance walked by minutes in the 6-minute walking test. Results Of the patients, 9 (13.4%) were categorized as deficiency (<12 ng/mL), 10 (14.9%) had inadequacy (≥12 and <20 ng/mL) and 48 (71.6%) had sufficiency (≥ 20 ng/mL) level of vitamin D. There was a significant correlation between vitamin D level and body fat mass (r=-0.29, p=0.017), BMI (r=-0.29, p=0.014), hip circumference (r=-0.28, p=0.021) and left quadriceps muscle strength (r=-0.288, p=0.018). There was no correlation between vitamin D level, 6 minutes walking speed, body muscle mass, right quadriceps muscle strength and hand grip strength (p>0.05). Conclusion In this study, although vitamin D level was associated with left lower extremity muscle strength in patients with MetS, it was not associated with other sarcopenia parameters such as muscle mass, upper extremity muscle strength and walking speed. The relationship between vitamin D level, fat mass and body composition seen in our study may be due to altered lipid metabolism responses. We think that the effects of vitamin D on sarcopenia in MetS should be prospectively examined in a larger sample including elderly patients and considering the vitamin D intake.

Source: European Journal of Preventive Cardiology

DOI: 10.1093/eurjpc/zwad125.118