Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems
Year: 2023
Type: article
Abstract: Diabetes mellitus, a group of metabolic disorders characterized by high levels of blood glucose caused by insulin defect or impairment, is a major risk factor for cardiovascular diseases and related mortality. Patients with diabetes experience a state of chronic or intermittent hyperglycemia resulting in damage to the vasculature, leading to micro- and macro-vascular diseases. These conditions are associated with low-grade chronic inflammation and accelerated atherosclerosis. Several classes of leukocytes have been implicated in diabetic cardiovascular impairment. Although the molecular pathways through which diabetes elicits an inflammatory response have attracted significant attention, how they contribute to altering cardiovascular homeostasis is still incompletely understood. In this respect, non-coding RNAs (ncRNAs) are a still largely under-investigated class of transcripts that may play a fundamental role. This review article gathers the current knowledge on the function of ncRNAs in the crosstalk between immune and cardiovascular cells in the context of diabetic complications, highlighting the influence of biological sex in such mechanisms and exploring the potential role of ncRNAs as biomarkers and targets for treatments. The discussion closes by offering an overview of the ncRNAs involved in the increased cardiovascular risk suffered by patients with diabetes facing Sars-CoV-2 infection.
Source: Cardiovascular Diabetology
Institutions: MultiMedica, IRCCS Policlinico San Donato, Imperial College London, Medizinische Hochschule Hannover, La Manufacture - Haute école des arts de la scène, Instituto de Salud Carlos III, Hospital Universitari Arnau de Vilanova, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Centro de Investigación Biomédica en Red, Instituto de Investigación Biomédica de Lleida, Leiden University Medical Center, Universitat de València, University of Iceland, Luxembourg Institute of Health
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,690
Funders: British Heart Foundation, Imperial College London, European Commission, Deutsche Forschungsgemeinschaft, Fonds National de la Recherche Luxembourg, Fondazione Telethon, Ministero della Salute, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Generalitat Valenciana, Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche, Ministerio de Ciencia e Innovación, Háskóli Íslands, Instituto de Salud Carlos III, Horizon 2020, European Regional Development Fund
Awards: The BHF Chair of Cardiovascular Science, G1444097651, A diagnostic test to improve surveillance and care of COVID-19 patients, Research Excellence (round 3), G1638103087, G2809275475, Small noncoding RNAs and their chemical modifications in cardiovascular disease, G3499604025, G3838406587, G4134805476, Exosomes in ischaemic heart disease accompanied with diabetes mellitus: from pathogenic mediators to novel therapeutic agents (renewal), G4709824544, G5323068761, G60520938, CardioReGenix: Development of Next-Generation Gene Therapies for Cardiovascular Disease, G6707857717, G671044162, G683891793, G7666839654, G7675906760, G8088613886, G8860257818
OpenAlex ID: W4378072002