Tumor-neutrophil crosstalk promotes in vitro and in vivo glioblastoma progression
Year: 2023
Type: article
Abstract: Introduction: The tumor microenvironment (TME) of glioblastoma (GB) is characterized by an increased infiltration of immunosuppressive cells that attenuate the antitumor immune response. The participation of neutrophils in tumor progression is still controversial and a dual role in the TME has been proposed. In this study, we show that neutrophils are reprogrammed by the tumor to ultimately promote GB progression. Methods: assays, we demonstrate the existence of bidirectional GB and neutrophil communication, directly promoting an immunosuppressive TME. Results and discussion: Neutrophils have shown to play an important role in tumor malignancy especially in advanced 3D tumor model and Balb/c nude mice experiments, implying a time- and neutrophil concentration-dependent modulation. Studying the tumor energetic metabolism indicated a mitochondria mismatch shaping the TME secretome. The given data suggests a cytokine milieu in patients with GB that favors the recruitment of neutrophils, sustaining an anti-inflammatory profile which is associated with poor prognosis. Besides, glioma-neutrophil crosstalk has sustained a tumor prolonged activation via NETs formation, indicating the role of NFκB signaling in tumor progression. Moreover, clinical samples have indicated that neutrophil-lymphocyte ratio (NLR), IL-1β, and IL-10 are associated with poor outcomes in patients with GB. Conclusion: These results are relevant for understanding how tumor progression occurs and how immune cells can help in this process.
Source: Frontiers in Immunology
Authors: Dominique S. Rubenich, Priscila O. de Souza, Natalia Omizzollo, Mariana R. Aubin, Paulo J. Basso, Luisa M. Silva, Eloisa M. da Silva, Fernanda C. Teixeira, Gabriela F.S. Gentil, Jordana L. Domagalski, Maico T. Cunha, Kerolainy A. Gadelha, Leonardo F. Diel, Nicolly E. Gelsleichter, Aline S. Rubenich, Gabriela S. Lenz, Aline M. de Abreu, Giselle M. Kroeff, Ana H. Paz, Fernanda Visioli, Marcelo L. Lamers, Marcia R. Wink, Paulo V. Worm, Anelise B. Araújo, Jean Sévigny, Niels O. S. Câmara, Nils Ludwig, Elizandra Braganhol
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,295
Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Fundação Instituto de Pesquisas Econômicas, Natural Sciences and Engineering Research Council of Canada
OpenAlex ID: W4378072058