The in vitro study of interaction between antacids and anti-diabetic drug sitagliptin in the treatment of type II diabetes.
Year: 2023
Type: paratext
Abstract: Hyperglycemia is a long-lasting syndrome that occurs either when the pancreas cannot produce enough insulin, or the body cannot effectively utilize that insulin to regulate blood sugar levels.Non-insulin-dependent hyperglycemia, also known as type II diabetes, causes a common consequence of severe damage to many of the body's organs mainly the blood vessels and nerves.The majority of people around the world are suffering from non-insulindependent diabetes.The present work showed a great effort to investigate any possible interaction between antacids and sitagliptin (anti-diabetic drug) in the treatment of type II diabetes with gastrointestinal tract problems.The in vitro studies were carried out in simulated gastric juice pH 2.0 and intestinal pH 7.4 at 37C.MgCO 3 , NaHCO 3 , Mg(OH) 2 , Al(OH) 3 and CaCO 3 were used as antacids in these studies.It has been observed that % release of sitagliptin was significantly enhanced in the presence of calcium carbonate and magnesium carbonates.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4379031007