Necessity for surveillance for hepatocellualr carcinoma in older patients with chronic hepatitis C who achieved sustained virological response
Year: 2023
Type: article
Study design: Observational Study
Abstract: Background and Aim: Hepatocellular carcinoma (HCC) surveillance in low-risk patients (annual incidence <1.5%) is not recommended per the American Association for the Study of Liver Diseases guidelines. Because patients with chronic hepatitis C with non-advanced fibrosis who have achieved sustained virological response (SVR) have a low risk of HCC, HCC surveillance is not recommended for them. However, aging is a risk factor for HCC; threfore, the necessity for HCC surveillance in older patients with non-advanced fibrosis needs to be verified. Methods: This multicenter, prospective study enrolled 4993 patients with SVR (1998 patients with advanced fibrosis and 2995 patients with non-advanced fibrosis). The HCC incidence was examined with particular attention to age. Results: < 0.001). HCC incidence stratified by age and sex was investigated in patients with non-advanced fibrosis. The HCC incidence in the 18-49, 50s, 60s, 70s, and ≥80 age groups were 0.26, 1.3, 1.8, 1.7, and 2.9 per 100 person-years in men, and 0.00, 0.32, 0.58, 0.49, and 0.57 per 100 person-years in women, respectively. Conclusions: Male patients with non-advanced fibrosis aged ≥60 years have a higher risk of developing HCC and, thus, require HCC surveillance.
Source: JGH Open
DOI: 10.1002/jgh3.12914
Authors: Shun Ishido, Nobuharu Tamaki, Masayuki Kurosaki, Nami Mori, Keiji Tsuji, Chitomi Hasebe, Toshie Mashiba, Hironori Ochi, Yutaka Yasui, Takehiro Akahane, Koichiro Furuta, Haruhiko Kobashi, Hideki Fujii, Toru Ishii, Hiroyuki Marusawa, Masahiko Kondo, Atsunori Kusakabe, Hideo Yoshida, Yasushi Uchida, Toshifumi Tada, Shinichiro Nakamura, Akari Mitsuda, Chikara Ogawa, Hirotaka Arai, Toshimitsu Murohisa, Minoru Uebayashi, Namiki Izumi
Institutions: Musashino Red Cross Hospital, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Japanese Red Cross Asahikawa Hospital, Matsuyama Red Cross Hospital, Japanese Red Cross Ishinomaki Hospital, Masuda Red Cross Hospital, Okayama Red Cross General Hospital, Kyoto first Red Cross hospital, Akita Red Cross Hospital, Osaka Red Cross Hospital, Otsu Red Cross Hospital, Japanese Red Cross Nagoya Daini Hospital, Japanese Red Cross Medical Center, Matsue Red Cross Hospital, Himeji Red Cross Hospital, Takamatsu Red Cross Hospital, Maebashi Red Cross Hospital, Ashikaga Red Cross Hospital, Japanese Red Cross Kitami Hospital
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,200
OpenAlex ID: W4379529006