Year: 2023
Type: review
Abstract: Uterine vascular remodeling is intrinsic to the cycling and early pregnant endometrium. Maternal regulatory factors such as ovarian hormones, VEGF, angiopoietins, Notch, and uterine natural killer cells significantly mediate these vascular changes. In the absence of pregnancy, changes in uterine vessel morphology and function correlate with different stages of the human menstrual cycle. During early pregnancy, vascular remodeling in rodents and humans results in decreased uterine vascular resistance and increased vascular permeability necessary for pregnancy success. Aberrations in these adaptive vascular processes contribute to increased risk of infertility, abnormal fetal growth, and/or preeclampsia. This Review comprehensively summarizes uterine vascular remodeling in the human menstrual cycle, and in the peri- and post-implantation stages in rodent species (mice and rats).
Source: JCI Insight
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,100
Funders: March of Dimes Foundation, National Institutes of Health, College of Engineering, Michigan State University, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1547258562, Innate Immune Mechanisms at the Maternal-Fetal Interface in Normal and Superovulatory Pregnancy, G75938025, Metabolic Basis of Disease - Phase 2, Reproductive and Developmental Sciences Training Program - T32, Signaling mechanisms that modulate uterine 3D structure for pregnancy success
OpenAlex ID: W4379740940