A near-infrared light-activatable Ru( ii )-coumarin photosensitizer active under hypoxic conditions

Year: 2023

Type: article

Abstract: ). The induction of ROS-mediated cancer cell death upon low-energy wavelength irradiation along with the low dark toxicity exerted by this Ru(ii)-coumarin conjugate could circumvent tissue penetration issues while alleviating the hypoxia limitation of PDT. As such, this strategy could pave the way to the development of novel NIR- and hypoxia-active Ru(ii)-based theragnostic PSs fuelled by the conjugation of tunable, low molecular-weight COUPY fluorophores.

Source: Chemical Science

DOI: 10.1039/d3sc01844j

Authors: Enrique Ortega-Forte, Anna Rovira, Marta López-Corrales, Alba Hernández-García, Francisco José Ballester, Eduardo Izquierdo-García, Mireia Jordà-Redondo, Manel Bosch, Santi Nonell, María Dolores Santana, José Ruiz, Vicente Marchán, Gilles Gasser

Institutions: Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Centre National de la Recherche Scientifique, Chimie ParisTech - PSL, Université Paris Sciences et Lettres, Chimie Biologique pour le Vivant, Institute of Chemistry for Life and Health Sciences, Institut Químic de Sarrià, Universitat Ramon Llull, Centres Científics i Tecnològics de la Universitat de Barcelona

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: European Commission, Agence Nationale de la Recherche, Generalitat de Catalunya, Federación Española de Enfermedades Raras, Universidad de Murcia, Ministerio de Ciencia e Innovación, Universitat de Barcelona, European Research Council, Agencia Estatal de Investigación, H2020 European Research Council, Ministerio de Universidades

OpenAlex ID: W4379879413