Clinico-virological profile of severe acute respiratory infections in children admitted in pediatric ICU/high dependency unit
Year: 2022
Type: article
Study design: Observational Study
Abstract: Background: Viral etiologies responsible for acute respiratory infections in our region are poorly understood or studied, particularly among hospitalized children. Lacking etiologic diagnosis is the main reason that most of the cases suffer unnecessary or inappropriate prescription of antibiotics. Objectives: This study was done to know clinic-virological profile of severe acute respiratory infections in children admitted to pediatric intensive care unit or high dependency unit in a tertiary care hospital. Materials and Methods: Respiratory samples were collected and screened for viruses by utilizing multiplex real-time polymerase chain reaction (PCR) assay. Results: Viral PCR detection rate was 82.9%. A total of 69% of isolates were single virus and 31% were coinfection. Among the viral isolates, respiratory syncytial virus (RSV) A, B was the most common viral isolate (27.6%), followed by adenovirus (23.42%) and bocavirus (12.66%). RSV A, B showed an age predilection for 1–5 years. RSV A, B was the predominant isolate in children having acute respiratory distress syndrome, need for invasive ventilation and prolonged intensive care unit stay and it showed a seasonal prevalence in the months of August to December with peak incidence during October. Conclusion: Overall positivity was 82.9%. RSV A, B was the most predominant virus.
Source: Pediatric Companion
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4380433803