Cytokine storm in individuals with severe COVID-19 decreases endothelial cell antioxidant defense via downregulation of the Nrf2 transcriptional factor
Year: 2023
Type: article
Abstract: We demonstrate that endothelial cell dysfunction in SARS-CoV-2-infected individuals is linked to decreased activity of the major antioxidant system regulator, the Nrf2 transcription factor. We provide evidence that this phenomenon relies on IL-6, an important cytokine involved in the pathophysiology of COVID-19. Our data support the view that Nrf2 activation is a potential therapeutical strategy to prevent oxidative stress and vascular inflammation in severe cases of COVID-19.
Authors: Daniel Rodrigues, Mirele R. Machado, Juliano V. Alves, Thais F. C. Fraga-Silva, Ronaldo B. Martins, Ligia C. B. Campos, Daniely F. Francisco, Ariel E. S. Couto, Vânia L. D. Bonato, Eurico Arruda, Christiane Becari, Maria Auxiliadora-Martins, Paulo Louzada-Júnior, Rafael M. Costa, Rita C. Tostes
Institutions: Universidade de São Paulo, Universidade Federal de Jataí
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4380869705