Direct reductive amination of functionalized aldehydes with aniline derivatives of purines and 7-deazapurines
Year: 2023
Type: article
Abstract: ". The set-up procedure surmounts some of the drawbacks of "in batch" protocols by avoiding the handling of reductant reagents, long reaction times and tedious work-ups. The here described procedure allows a high conversion into the reductive amination products together with an easy work-up by just evaporation. More interestingly, this set-up does not require the presence of acids so that acid-sensitive protecting groups can be present both at the aldehyde and at the heterocycle.
Source: Organic & Biomolecular Chemistry
DOI: 10.1039/d3ob00822c
Institution: Instituto de Química Médica
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Awards: G1175115578, G1599646647, G1855990336, G1953887145, G2262748287, G2309174360, G2426432956, G2601397997, G2660406951, G2745972340, G2840684682, G300979063, G3480869486, G3681454997, G3690828678, G4042783231, G425668148, G430777504, G4340597044, G5080475149, G5195188938, G5361907258, G5421974903, G6218905885, G6304488753, G6597146483, G7084143925, G8684520763, G8888022036, G99296377
OpenAlex ID: W4380997240