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Anti-Alzheimer activity of new coumarin-based derivatives targeting acetylcholinesterase inhibition

Year: 2023
Type: article
Abstract: study investigated the amelioration in the cognitive function of AD-rats treated with 4c through the T-maze and beam balance behavioural tests. Also, 4c detectably ameliorated MDA and GSH, reaching 90.64 and 27.17%, respectively, in comparison to the standard drug (90.64% and 35.03% for MDA and GSH, respectively). The molecular docking study exhibited a good fitting of compound 4c in the active site of the AChE enzyme and a promising safety profile. Compound 4c exhibited a promising anti-Alzheimer's disease efficiency compared to the standard drug donepezil.
Source: RSC Advances
DOI: 10.1039/d3ra02344c
Authors: Nahla N. Kamel, Hanan F. Aly, Ghadha I. Fouad, Somaia S. Abd El-Karim, Manal M. Anwar, Yasmin M. Syam, Samia A. Elseginy, Kawkab A. Ahmed, Hoda F. Booles, Mohamed B. Shalaby, Wagdy K. B. Khalil, Rajat Sandhir, Sonam Deshwal, Maha Z. Rizk
Language: English
Subfield: Pharmacology
Field: Medicine
Open Access status: gold
Estimated APC paid: $1,042
OpenAlex ID: W4381336052
FWCI: 10.04
Cites: 40
Cited by: 65
Related to: 10