Work

Trans -palmitoleic acid, a dairy fat biomarker, stimulates insulin secretion and activates G protein-coupled receptors with a different mechanism from the cis isomer

Year: 2023

Type: article

Abstract: Trans - and cis palmitoleic acids stimulate insulin secretion from pancreatic β cells with a similar potency. Both isomers activate GPR40, GPR55, GPR119, and GPR120 receptors with similar potency but with activation of different signaling pathways.

Source: Food & Function

DOI: 10.1039/d2fo03412c

Authors: Eliza Korkus, Marcin Szustak, Rafal Madaj, Arkadiusz Chworos, Anna Drzazga, Maria Koziołkiewicz, Grzegorz Dąbrowski, Sylwester Czaplicki, Iwona Konopka, Edyta Gendaszewska-Darmach

Institutions: Lodz University of Technology, Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk, University of Warsaw, Polish Academy of Sciences, University of Warmia and Mazury in Olsztyn

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Narodowe Centrum Nauki, Narodowym Centrum Nauki

Award: G4258758067

OpenAlex ID: W4381930833

FWCI: 2.609

Cites: 57

Cited by: 11

Related to: 10