Work

Bioavailability study of Posaconazole in rats after oral Poloxamer P188 Nano-micelles and oral Posaconazole pure drug

Year: 2023

Type: article

Abstract: Posaconazole (POCZ) is a triazole antifungal with poor solubility and low bioavailability, so this work is aimed to compare between bioavailability parameters of pure POCZ and the prepared lyophilized POCZ nano-micelles. In this study, twelve Wistar rats were used with a weight of 200±20g and divided into twice groups (each group with six animals). The dose of 10mg/kg of pure POCZ and POCZ nano-micelles was administered to rats by oral gavage after reconstitution with water. The determina

Source: Journal Of Advanced Pharmacy Education And Research

DOI: 10.51847/q59uyvrmy3

Authors: Alaa Abdulelah Abdulqader, Nawal Ayash Rajab

Institutions: University of Tikrit, University of Baghdad

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: University of Baghdad