Palivizumab Prophylaxis in Infants and Young Children at Increased Risk of Hospitalization for Respiratory Syncytial Virus Infection
Year: 2023
Type: article
Abstract: Guidance from the American Academy of Pediatrics (AAP) for the use of palivizumab prophylaxis against respiratory syncytial virus (RSV) was first published in a policy statement in 1998. AAP recommendations have been updated periodically to reflect the most recent literature regarding children at greatest risk of severe RSV disease. Since the last update in 2014, which refined prophylaxis guidance to focus on those children at greatest risk, data have become available regarding the seasonality of RSV circulation, the incidence and risk factors associated with bronchiolitis hospitalizations, and the potential effects of the implementation of prophylaxis recommendations on hospitalization rates of children with RSV infection. This technical report summarizes the literature review by the Committee on Infectious Diseases, supporting the reaffirmation of the 2014 AAP policy statement on palivizumab prophylaxis among infants and young children at increased risk of hospitalization for RSV infection. Review of publications since 2014 did not support a change in recommendations for palivizumab prophylaxis and continues to endorse the guidance provided in the 2021 Red Book.
Source: PEDIATRICS
Authors: Mary T. Caserta, Sean T. O’Leary, Flor M. Munoz, Shawn L. Ralston, Sean T. O’Leary, James D. Campbell, Monica I. Ardura, Ritu Banerjee, Kristina A. Bryant, Mary T. Caserta, Jeffrey S. Gerber, Chandy C. John, Athena P. Kourtis, Angela Myers, Pia Pannaraj, Adam J. Ratner, José R. Romero, Samir S. Shah, Kenneth M. Zangwill, Yvonne A. Maldonado, Flor M. Munoz, Shawn L. Ralston, David W. Kimberlin, Elizabeth D. Barnett, Ruth Lynfield, Mark H. Sawyer, Henry H. Bernstein, Karen M. Farizo, Lisa M. Kafer, David Kim, Eduardo López Medina, Denee Moore, Lakshmi Panagiotakopoulos, Laura Sauvé, Jeffrey R. Starke, Jennifer Thompson, Kay M. Tomashek, Melinda Wharton, Charles R. Woods, Jennifer M. Frantz
Institutions: University of Rochester Medicine, Children's Hospital Colorado, University of Colorado Anschutz, Baylor College of Medicine, Texas Children's Hospital, Johns Hopkins University, University of Rochester, American Thoracic Society, National Institutes of Health, Pediatric Infectious Diseases Society
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4382011185