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Allergen-specific IgG4 increase in atopic dermatitis with long-term dupilumab use

Year: 2023
Type: article
Abstract: This small-scale prospective study investigated the changes in antigen-specific IgG4 (sIgG4) that occur during long-term dupilumab treatment in patients with atopic dermatitis. While dupilumab has been reported to have an inhibitory effect on B-cell maturation, the increase in sIgG4 during dupilumab treatment may indicate that dupilumab indirectly improves allergies in those predisposed to them. We present the possibility of a new therapeutic effect of long-term dupilumab use.
DOI: 10.1093/bjd/ljad207
Authors: Mariko Ogawa-Momohara, Yoshinao Muro, Chiaki Murase, Tomoki Taki, Kana Tanahashi, Yuta Yamashita, Haruka Koizumi, Ryo Fukaura, Takuya Takeichi, Masashi Akiyama
Institution: Nagoya University
Language: English
Subfield: Dermatology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,249
OpenAlex ID: W4382344729
FWCI: 2.016
Cites: 5
Cited by: 8
Related to: 10