Work

Electrochemical Determination of Paracetamol Using Gold Nanoparticles – Application in Tablets and Human Fluids

Year: 2011

Type: article

Abstract: A highly sensitive and simple method was investigated for the determination of acetaminophen (ACOP) using gold nanoparticles modified carbon paste electrode (GNMCPE). GNMCPE displayed excellent electrochemical catalytic activities towards the oxidation of ACOP. Under optimized experimental conditions in differential pulse voltammetry (DPV) technique, the sensitivity of ACOP was improved greatly and gave a linear response over the ranges 5.0×10−8 to 2.7 ×10−4 mol L−1 with a detection limit of 1.46 x 10-8 mol L−1. More over, the present method was also applied for the determination of ACOP in the presence of common interferents, namely ascorbic acid (AA) and uric acid (UA) and in binary mixture with dopamine (DA). This method could readily discriminate ACOP from DA. And an electrochemical detection of ACOP in spiked urine sample was succeeded with satisfactory results. This procedure was also successfully applied for the assay of paracetamol in pharmaceutical formulations.

Source: International Journal of Electrochemical Science

DOI: 10.1016/s1452-3981(23)18390-8

Authors: Nada F. Atta, Ahmed Galal, Shereen M. Azab

Institution: Cairo University

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,670