Finite Element Analysis of Thoracolumbar Junction Transpedicular Fixation Variants After Resection of the Th12 Vertebra While Forward Bending
Year: 2023
Type: article
Abstract: Worldwide, acute generalized peritonitis (AGP) is a common medical and surgical emergency and a major cause of mortality.Despite the obvious successes of diagnostics, the use of various antibacterial drugs of the new generation, the introduction of modern methods of minimally invasive treatment, the mortality rate in AGP ranges from 12.5% to 39.2%.The basis of the severe course and high mortality rates in acute peritonitis is often concomitant pathology, among which obesity is present in 7.5% to 14.0%.Aimto study the state of the indicators of the nitric oxide system in the body of experimental animals with simulated AGP against the background of obesity and compare them with groups of obese animals and with animals with AGP.Materials and methods.64 white Wistar rats were used, which were divided into three groups: the main group -24 animals with GPP simulation on the background of obesity; comparison group -8 animals with obesity simulation; another comparison group -24 animals with GPP modeling; control -8 intact animals.GPP was modeled by injecting 10% filtered fecal suspension into the abdominal cavity.Obesity was simulated using a high-calorie diet.Using the photospectrometric method, the content of indicators of the nitrogen nitrite system in the blood and liver of animals was determined.Results.After analyzing the indicators of nitrites and nitrates in the blood serum of the main group and the comparison group, we established a clear tendency to increase depending on the increase in the duration of the experiment after GPP simulation in these two studied groups.On the 1st day, the level of NOx metabolites in the blood serum of the group of animals with GPP on the background of obesity was significantly higher than that in the group of animals with isolated GPP (by 9%), on the 3rd day -by 8%, and on the 7th day -by 7% respectively (p<0.05).Comparing the indicators of NO-synthase activity in the liver of the rats of the main group and the comparison group, we obtained higher indicators in the animals of the GPP group and the background of obesity during all periods of the experiment: on the 1st day -by 16%, on the 3rd day -by 14%, and on the 7th day -by 13% (р<0.05).Conclusion.Therefore, based on the statistically significantly higher levels of NO-synthase in the liver and the content of nitrates and nitrites in the blood serum of animals with АGP on the background of obesity compared to animals with isolated obesity or animals with АGP, we established a significant increase in nitrooxidative stress mechanisms during all periods of the experiment in animals with a combination of АGP and obesity.
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4382601034