Association of Foot Symptoms With Decreased Time to All‐Cause Mortality: The Johnston County Osteoarthritis Project
Year: 2023
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Adults with foot symptoms (ie, pain, aching, or stiffness) may be at increased risk of reduced time to all-cause mortality. The purpose of this study was to evaluate whether foot symptoms are independently associated with all-cause mortality in older adults. METHODS: We analyzed longitudinal data from 2613 participants from the Johnston County Osteoarthritis Project, a longitudinal population-based cohort of adults 45 years of age and older. Participants completed questionnaires at baseline to determine presence of foot symptoms and covariable status. Baseline walking speed was measured via an 8-foot walk test. To examine the association of foot symptoms with time to mortality, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox regression models, adjusted for potential confounders. RESULTS: , 65% were women, and 33% were Black. Moderate to severe foot symptoms were associated with reduced time to mortality after adjustment for demographics, comorbidities, physical activity, and knee and hip symptoms (HR = 1.30, 95% CI 1.09-1.54). Importantly, this association was not modified by walking speed or diabetes. CONCLUSION: Individuals with foot symptoms had an increased hazard of all-cause mortality compared with those with no foot symptoms. These effects were independent of key confounders and were not moderated by walking speed. Effective interventions to identify and manage at least moderate foot symptoms may reduce the risk of decreased time to mortality.
Source: Arthritis Care & Research
DOI: 10.1002/acr.25186
Institutions: University of North Carolina at Chapel Hill, Nova Southeastern University, Beth Israel Deaconess Medical Center, Harvard University, Hebrew SeniorLife, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, MRC Lifecourse Epidemiology Unit, University of Southampton, La Trobe University, University of Nebraska Medical Center
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,640
Funders: National Institute for Health and Care Research, National Institutes of Health, Centers for Disease Control and Prevention, University of North Carolina at Chapel Hill, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Chronic Disease Prevention and Health Promotion
Awards: G1027239709, G1170704527, JOHNSTON COUNTY OSTEOARTHRITIS PROJECT: ARTHRITIS, DISABILITY, AND OTHER CHRONIC DISEASES, THE JOHNSTON COUNTY OA PROJECT: ARTHRITIS AND DISABILITY, NIHR Senior Investigator Award, The optimisation of foot care for people with arthritis, G4109785237, NIAMS Multidisciplinary Clinical Research Center, NIAMS Multidisciplinary Clin Res Ctr: Rheumatic Diseases, Mortality in a community sample of adults with arthritis, MULTIPURPOSE ARTHRITIS &MUSCULOSKELETAL DISEASES CENTER, G781900440, G7920972074, G8125002010, G8384987212, G8657475223, UNC-CH Summer Research Training in Aging for Medical Students, UNC Core Center for Clinical Research
OpenAlex ID: W4382632269