Work

D‐2‐hydroxyglutarate suppresses allergic sensitization in a murine model of experimental asthma

Year: 2023

Type: article

Abstract: To the Editor,Asthma is a chronic inflammatory disease affecting the airways which is characterized by reversible airflow obstruction, bronchial hyperresponsiveness, and airway remodeling.In allergic asthma, this airway pathology is mediated by Type 2 cytokines (IL-4, IL-5, and IL-13) and allergen-specific IgE.IL-4, IL-5, and IL-13 are predominantly produced by lung resident T helper 2 (Th2) cells and Type 2 innate lymphoid cells.The production of allergen-specific IgE from B cells is driven by a subset of IL-4 and IL-13 producing T follicular helper cells termed T follicular helper 13 (Tfh13) cells.1,2 The initiation of these T-cell responses is mediated by dendritic cells (DCs).The mechanisms by which DCs regulate Th2 and Tfh13 polarization, however, are unclear.Several genome-wide association studies have identified that single-nucleotide polymorphisms (SNPs) in the D2HGDH locus are associated with allergic asthma and allergic rhinitis risk, with the G allele of rs34290285 associated with a lower risk of disease.3 The D2HGDH gene encodes the enzyme D-2hydroxyglutarate dehydrogenase (D2HGDH), which converts D-2-hydroxyglutarate (D2HG) to α-ketoglutarate (α-KG).To elucidate the functional consequences of these SNPs, the regulatory landscape of the D2HGDH locus was analyzed using the ENCODE database.We found that the sentinel

Source: Allergy

DOI: 10.1111/all.15809

Authors: Anuj Tharakan, Ankit Kumar, Jeremy Allegood, Lauren Ashley Cowart, Daniel H. Conrad, Rebecca K. Martin

Institutions: Virginia Commonwealth University, Hunter Holmes McGuire VA Medical Center

Language: English

Topic: Asthma and respiratory diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,900