Berberine mitigates acetamiprid-induced hepatotoxicity and inflammation via regulating endogenous antioxidants and NF-κB/TNF-α signaling in rats
Year: 2023
Type: article
Abstract: Acetamiprid (ACMP) is a neonicotinoid insecticide used on a large scale and has been reported for oxidative stress mediated toxicity and physiological alterations in mammals. The plant-derived natural antioxidant berberine (BBR) possesses protective potential against inflammation, structural changes and cellular toxicity. The current study aimed to investigate the toxic effects of ACMP exposure and the antioxidative and anti-inflammatory efficacy of BBR in rat liver tissue. The results showed that acetamiprid exposure (21.7 mg/kg b.wt) significantly elicited oxidative stress as evidenced by lipid peroxidation, protein oxidation, depletion of endogenous antioxidants. Further, ACMP exposure elevated NF-κB, TNF-α, IL-1β, IL-6 and IL-12 expression and caused structural alterations in liver tissue. Biochemical results showed that BBR treatment (150 mg/kg b.wt) reduced damage to lipids and proteins, replenished GSH, enhanced SOD, catalase activities and offered antioxidative effects against ACMP toxicity. Also, BBR suppressed inflammation by regulating NF-κB/TNF-α signaling in hepatic tissue of ACMP intoxicated rats. Histopathological examination confirmed the hepatoprotective effects of BBR. Our findings indicate that BBR might be speculated as potential therapeutic agent against oxidative stress mediated hepatotoxicity.
Institution: Maharshi Dayanand University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4383621653