Values of coagulation parameters in hospitalized patients with SARS-CoV-2 infection intheUniversity Clinical Hospital Mostar
Year: 2023
Type: article
Study design: Observational Study
Abstract: Background: The aim of this study was to determine the presence of coagulation parameter disorders in patients hospitalized due to COVID-19 and to investigate the relationship between the abnormalities of coagulation parameters and the final outcome.Methods: We performed a retrospective cohort study of 81 patients admitted to the University Clinical Hospital Mostar, due to respiratory infection by SARS-CoV-2, in the period from March 15th to May 15th, 2021.Subjects were divided into two groups according to the final outcome.We analyzed age, sex, comorbidity frequency and parameters of coagulation function.Main findings: Of the 81 patients, 42 died and 72.7% died in the Respiratory Center (p<0.001).Two-thirds of the respondents were male.The mean age of all respondents was 72.88±14.21years.Nonsurvivors were significantly older than survivors (p=0.002).Previous chronic disease was confirmed in 84% of the subjects and the most common comorbidity was arterial hypertension.D-dimers were elevated in 95% of the subjects.Non-survivors had a statistically significant prolongation of APTT in seconds (p=0.005)than survivors, while in other coagulation parameters, there was no statistical significance with respect to the severity of the clinical status and the final outcome.Principal conclusions: SARS-CoV-2 infection is associated with abnormalities in the parameters of coagulation function.Moreover, APTT is an important factor for prognosis assessment in patients with COVID-19.
Institutions: University of Mostar, University Clinical Hospital Mostar
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4384068636