From Eberthella typhi to Salmonella Typhi: The Fascinating Journey of the Virulence and Pathogenicity of Salmonella Typhi
Year: 2023
Type: review
Abstract: Salmonella Typhi (S.Typhi), the invasive typhoidal serovar of Salmonella enterica that causes typhoid fever in humans, is a severe threat to global health.It is one of the major causes of high morbidity and mortality in developing countries.According to recent WHO estimates, approximately 11-21 million typhoid fever illnesses occur annually worldwide, accounting for 0.12-0.16 million deaths.Salmonella infection can spread to healthy individuals by the consumption of contaminated food and water.Typhoid fever in humans sometimes is accompanied by several other critical extraintestinal complications related to the central nervous system, cardiovascular system, pulmonary system, and hepatobiliary system.Salmonella Pathogenicity Island-1 and Salmonella Pathogenicity Island-2 are the two genomic segments containing genes encoding virulent factors that regulate its invasion and systemic pathogenesis.This Review aims to shed light on a comparative analysis of the virulence and pathogenesis of the typhoidal and nontyphoidal serovars of S. enterica.
Source: ACS Omega
Institution: Indian Institute of Science Bangalore
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,685
Funders: Indian Institute of Science, Department of Biotechnology, Ministry of Science and Technology, India, Department of Science and Technology, Ministry of Science and Technology, India, Indian Council of Medical Research, Council of Scientific and Industrial Research, India, Department of Atomic Energy, Government of India, Center for Advanced Study, University of Illinois at Urbana-Champaign
OpenAlex ID: W4384297917