Work

A Tetradentate Ligand Enables Iron‐Catalyzed Asymmetric Hydrogenation of Ketones in a CO‐ or Isocyanide‐Free Fashion

Year: 2023

Type: article

Abstract: We herein reported the design and synthesis of a ferrocene-based tetradentate ligand that is featured with modular synthesis and rigid skeleton. Its iron(II) complex facilitates asymmetric direct hydrogenation of ketones without the participation of extra strong-field ligand such as CO and isocyanide. Hydride donor lithium aluminum hydride (LAH) converted non-reactive Fe(II) species to reactive Fe(II) hydride species. With this catalyst, various chiral alcohols including the intermediate for montelukast could be prepared with satisfactory yields and enantioinduction.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202301609

Authors: Lei Yang, Xuefeng Tan, Menglong Zhao, Jialin Wen, Xumu Zhang

Institutions: Southern University of Science and Technology, City University of Hong Kong, Jiangsu Hengrui Medicine (China)

Language: English

Topic: Asymmetric Hydrogenation and Catalysis

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Guangdong Provincial Key Laboratory Of Catalysis

Award: G128716482