Work

Inside Back Cover: Mechanochemistry‐Amended Barbier Reaction as an Expedient Alternative to Grignard Synthesis (Angew. Chem. Int. Ed. 39/2023)

Year: 2023

Type: article

Abstract: Mechanochemistry makes the next move in advancing organometallic synthesis. In their Research Article (e202305775), Riina Aav, Dzmitry G. Kananovich et al. report a mechanochemical adaptation of the Mg-mediated Barbier reaction, which overcomes the limitations of the classic solvent-based approach. Mechanochemical activation enables the rapid generation of Grignard reagents in situ, making the process resistant to air and allowing solid Brønsted acids to be used as additives to improve yields.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202310353

Authors: Jagadeesh Varma Nallaparaju, Tatsiana Nikonovich, Tatsiana Jarg, Danylo Merzhyievskyi, Riina Aav, Dzmitry G. Kananovich

Institutions: Tallinn University of Technology, National Academy of Sciences of Ukraine, Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar

Language: English

Topic: Coordination Chemistry and Organometallics

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4385456013

FWCI: 0.097

Cites:

Cited by: 1

Related to: 10