Work

A study of WZB117 as a competitive inhibitor of glucose transporter in high glucose treated PANC-1 cells by live-cell FTIR spectroscopy

Year: 2023

Type: article

Abstract: • Label-free FTIR can monitor drug-cell interaction in living PANC-1 cells in situ. • Significant differences (p < 0.05) found in spectra among high glucose and different concentration drug treated PANC-1 cells groups. • High glucose treated cells shown changes linked to glycogen. • WZB117-treated cells shown changes lowered in glycogen contents. • Live cell FTIR may assist in the study of relationship between concentration and duration of drug treatment.

Source: Talanta

DOI: 10.1016/j.talanta.2023.125031

Authors: Anchisa Poonprasartporn, Jin Xiao, K.L. Andrew Chan

Institution: King's College London

Language: English

Topic: Spectroscopy Techniques in Biomedical and Chemical Research

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,940