Malignancy Associated with Low-Risk HPV6 and HPV11: A Systematic Review and Implications for Cancer Prevention
Year: 2023
Type: review
Study design: Systematic Review
Abstract: High-risk human papillomavirus (HPV) is etiologically related to cervical cancer, other anogenital cancers and oropharyngeal carcinomas. Low-risk HPV, especially HPV6 and HPV11, cause genital warts and laryngeal papillomas. However, the accumulating data suggests that HPV6 and HPV11 may cause malignant lesions at non-cervical anatomic sites. This review aims to estimate the proportions of single and dual HPV6/11 infections in multiple cancers reported in the last 10 years in the Cochrane, Embasa and PubMed databases. Secondly, the genomes of HPV6/11 were compared with the most common high-risk genotype, HPV16, to determine the similarities and differences. A total of 11 articles were selected, including between one and 334 HPV+ cancer patients. The frequencies of single or dual HPV6/11 infections ranged between 0–5.5% for penile and 0–87.5% for laryngeal cancers and were null for vulvar, vaginal and oral cancers. The genomic similarities between HPV6/11 and HPV16 mainly involved the E7 gene, indicating a limited ability to block cell differentiation. The presence of single or dual HPV6/11 infections in variable proportions of penile and laryngeal cancers support the vaccination strategies that cover these genotypes, not only for preventing genital warts but also for cancer prevention. Other risk factors and co-carcinogens are likely to participate in epithelial carcinogenesis associated with low-risk HPV.
Source: Cancers
Institutions: Universidade Federal do Maranhão, Universidade Estadual do Maranhão, IPO Porto, Centro de Investigação do Instituto Português de Oncologia do Porto Francisco Gentil, University of Trás-os-Montes and Alto Douro, Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Universidade do Porto
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,892
Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão, Ministério da Ciência, Tecnologia e Ensino Superior, Ministério da Saúde, Fundação para a Ciência e a Tecnologia, European Regional Development Fund
Awards: G116629194, G1167214205, G1172344086, G1207375514, G131955077, G1391108171, G1516346500, G1524689937, G1530003254, G1559068809, G1578237752, G2027966439, G223797620, G2375406851, G2391950951, ALICE - Laboratório Associado em Engenharia Química, G2772965640, G2786777218, Sem título, G2883425841, G323769159, G3290056561, G3310365908, G3477649815, G3537227798, G390684045, G4311394972, G4316116677, G4410725045, G4617313937, Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia, G5088119131, G5485649731, G5530709631, G5538107981, Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia, G5789510585, G5963377275, G6146342933, G6248245625, G632455026, G6583122068, G6677885567, G6701175450, G6791167606, G6815844370, G6997928969, G73470787, G7584003722, G7949922267, G8113259479, G832823311, G840395847, G96847669
OpenAlex ID: W4385759481